contextual conditioning chamber Search Results


standard mouse fear conditioning chamber  (Med Associates Inc)
96
Med Associates Inc standard mouse fear conditioning chamber
Standard Mouse Fear Conditioning Chamber, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/standard mouse fear conditioning chamber/product/Med Associates Inc
Average 96 stars, based on 1 article reviews
standard mouse fear conditioning chamber - by Bioz Stars, 2026-05
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coulbourn chamber  (Coulbourn Instruments)
90
Coulbourn Instruments coulbourn chamber
Coulbourn Chamber, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
coulbourn chamber - by Bioz Stars, 2026-05
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contextual conditioning chamber  (Med Associates Inc)
97
Med Associates Inc contextual conditioning chamber
Contextual Conditioning Chamber, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/contextual conditioning chamber/product/Med Associates Inc
Average 97 stars, based on 1 article reviews
contextual conditioning chamber - by Bioz Stars, 2026-05
97/100 stars
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conditioning chamber  (Coulbourn Instruments)
90
Coulbourn Instruments conditioning chamber
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Conditioning Chamber, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/conditioning chamber/product/Coulbourn Instruments
Average 90 stars, based on 1 article reviews
conditioning chamber - by Bioz Stars, 2026-05
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operant conditioning chambers  (Coulbourn Instruments)
90
Coulbourn Instruments operant conditioning chambers
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Operant Conditioning Chambers, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/operant conditioning chambers/product/Coulbourn Instruments
Average 90 stars, based on 1 article reviews
operant conditioning chambers - by Bioz Stars, 2026-05
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standard operant chambers  (Coulbourn Instruments)
90
Coulbourn Instruments standard operant chambers
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Standard Operant Chambers, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/standard operant chambers/product/Coulbourn Instruments
Average 90 stars, based on 1 article reviews
standard operant chambers - by Bioz Stars, 2026-05
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plexiglas rodent conditioning chamber model e10-10  (Coulbourn Instruments)
90
Coulbourn Instruments plexiglas rodent conditioning chamber model e10-10
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Plexiglas Rodent Conditioning Chamber Model E10 10, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/plexiglas rodent conditioning chamber model e10-10/product/Coulbourn Instruments
Average 90 stars, based on 1 article reviews
plexiglas rodent conditioning chamber model e10-10 - by Bioz Stars, 2026-05
90/100 stars
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contextual fear-conditioning chamber  (Coulbourn Instruments)
90
Coulbourn Instruments contextual fear-conditioning chamber
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Contextual Fear Conditioning Chamber, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/contextual fear-conditioning chamber/product/Coulbourn Instruments
Average 90 stars, based on 1 article reviews
contextual fear-conditioning chamber - by Bioz Stars, 2026-05
90/100 stars
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truscan mouse chamber model h10-11m-pa  (Coulbourn Instruments)
90
Coulbourn Instruments truscan mouse chamber model h10-11m-pa
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Truscan Mouse Chamber Model H10 11m Pa, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/truscan mouse chamber model h10-11m-pa/product/Coulbourn Instruments
Average 90 stars, based on 1 article reviews
truscan mouse chamber model h10-11m-pa - by Bioz Stars, 2026-05
90/100 stars
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habitest fear conditioning chambers  (Coulbourn Instruments)
90
Coulbourn Instruments habitest fear conditioning chambers
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Habitest Fear Conditioning Chambers, supplied by Coulbourn Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/habitest fear conditioning chambers/product/Coulbourn Instruments
Average 90 stars, based on 1 article reviews
habitest fear conditioning chambers - by Bioz Stars, 2026-05
90/100 stars
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standard conditioning chamber  (Harvard Bioscience)
90
Harvard Bioscience standard conditioning chamber
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Standard Conditioning Chamber, supplied by Harvard Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/standard conditioning chamber/product/Harvard Bioscience
Average 90 stars, based on 1 article reviews
standard conditioning chamber - by Bioz Stars, 2026-05
90/100 stars
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fear conditioning chamber  (Panlab)
90
Panlab fear conditioning chamber
Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear <t>conditioning</t> (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.
Fear Conditioning Chamber, supplied by Panlab, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fear conditioning chamber/product/Panlab
Average 90 stars, based on 1 article reviews
fear conditioning chamber - by Bioz Stars, 2026-05
90/100 stars
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Image Search Results


Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear conditioning (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.

Journal: Biological psychiatry

Article Title: Diminished fear extinction in adolescents is associated with an altered somatostatin interneuron-mediated inhibition in the infralimbic cortex

doi: 10.1016/j.biopsych.2019.04.035

Figure Lengend Snippet: Suppression of fear extinction during adolescence. Average freezing in tone alone (TA), fear conditioning (FC) and fear extinction (FE) groups [A. pre-adolescent: tone alone (10 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 27) = 50.6, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 0.4; FC vs FE: p < 0.001)], [B. adolescent: tone alone (11 mice), fear conditioning (10 mice), and fear extinction (10 mice), comparison of freezing on day 3: (F (2, 28) = 17.2, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p < 0.001; FC vs FE: p = 1)], and [C. adult: tone alone (10 mice), fear conditioning (9 mice), and fear extinction (9 mice), comparison of freezing on day 3: (F (2, 25) = 26.7, p < 0.001; TA vs FC: p < 0.001; TA vs FE: p = 1; FC vs FE: p < 0.001)] on days 1 (tone alone or fear conditioning, 2 (extinction training) and 3 (memory test). A part of this behavioral data appeared in an earlier publication (11). We also observed a development-dependent decrease in fear acquisition (F (2, 55) = 12.9, p < 0.001; pre-adolescent vs adolescent: p = 0.25; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p = 0.005) and fear memory (F (2, 26) = 4.7, p = 0.014; pre-adolescent vs adolescent: p = 0.017; pre-adolescent vs adult: p < 0.016; adolescent vs adult: p = 0.93) in pre-adolescent, adolescent and adult mice.

Article Snippet: For conditioning, a mouse was placed in the conditioning chamber (context A) within a soundproof box (Coulbourn Instruments).

Techniques: Comparison

Experience-dependent modulation of PVIN-mediated inhibition of IL-mPFC layer 5 pyramidal neurons. A) Schematic presentation of light-evoked IPSC recording in the IL-mPFC layer 5 pyramidal neurons of PV-ChR2 mice. B) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of pre-adolescent tone alone (15 neurons/5 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (17 neurons/5 mice) (F (2, 44) = 4.9, p = 0.011; TA vs FC: p = 0.88; TA vs FE: p = 0.051; FC vs FE: p = 0.015). C) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adolescent tone alone (17 neurons/5 mice), fear conditioning (19 neurons/5 mice), and fear extinction groups (14 neurons/5 mice) (F (2, 47) = 2.12, p = 0.13; TA vs FC: p = 0.82; TA vs FE: p = 0.33; FC vs FE: p = 0.11). D) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adult tone alone (12 neurons/4 mice), fear conditioning (12 neurons/4 mice), and fear extinction groups (14 neurons/4 mice) (F (2, 35) = 0.15, p = 0.85; TA vs FC: p = 0.9; TA vs FE: p = 0.86; FC vs FE: p = 0.99). Comparison of IPSC amplitude in pre-adolescent, adolescent and adult TA groups: (F (2, 41) = 26.6, p = 0.007; pre-adolescent vs adolescent: p = 0.07; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p < 0.001). Upper panels show example traces. Scale: 5 ms/50 pA.

Journal: Biological psychiatry

Article Title: Diminished fear extinction in adolescents is associated with an altered somatostatin interneuron-mediated inhibition in the infralimbic cortex

doi: 10.1016/j.biopsych.2019.04.035

Figure Lengend Snippet: Experience-dependent modulation of PVIN-mediated inhibition of IL-mPFC layer 5 pyramidal neurons. A) Schematic presentation of light-evoked IPSC recording in the IL-mPFC layer 5 pyramidal neurons of PV-ChR2 mice. B) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of pre-adolescent tone alone (15 neurons/5 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (17 neurons/5 mice) (F (2, 44) = 4.9, p = 0.011; TA vs FC: p = 0.88; TA vs FE: p = 0.051; FC vs FE: p = 0.015). C) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adolescent tone alone (17 neurons/5 mice), fear conditioning (19 neurons/5 mice), and fear extinction groups (14 neurons/5 mice) (F (2, 47) = 2.12, p = 0.13; TA vs FC: p = 0.82; TA vs FE: p = 0.33; FC vs FE: p = 0.11). D) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adult tone alone (12 neurons/4 mice), fear conditioning (12 neurons/4 mice), and fear extinction groups (14 neurons/4 mice) (F (2, 35) = 0.15, p = 0.85; TA vs FC: p = 0.9; TA vs FE: p = 0.86; FC vs FE: p = 0.99). Comparison of IPSC amplitude in pre-adolescent, adolescent and adult TA groups: (F (2, 41) = 26.6, p = 0.007; pre-adolescent vs adolescent: p = 0.07; pre-adolescent vs adult: p < 0.001; adolescent vs adult: p < 0.001). Upper panels show example traces. Scale: 5 ms/50 pA.

Article Snippet: For conditioning, a mouse was placed in the conditioning chamber (context A) within a soundproof box (Coulbourn Instruments).

Techniques: Inhibition, Comparison

Experience-dependent modulation of SSTIN-mediated inhibition of IL-mPFC layer 5 pyramidal neurons. A) Schematic presentation of light-evoked IPSC recording in the IL-mPFC layer 5 pyramidal neurons of SST-ChR2 mice. B) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of pre-adolescent tone alone (13 neurons/5 mice), fear conditioning (14 neurons/5 mice), and fear extinction groups (15 neurons/5 mice) (F (2, 39) = 1.14, p = 0.33; TA vs FC: p = 0.57; TA vs FE: p = 0.6; FC vs FE: p = 1). C) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adolescent tone alone (18 neurons/6 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (18 neurons/5 mice) (F (2, 48) = 7.8, p = 0.001; TA vs FC: p = 0.003; TA vs FE: p = 0.006; FC vs FE: p = 1). D) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adult tone alone (15 neurons/6 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (18 neurons/5 mice) (F (2, 45) = 1.05, p = 0.36; TA vs FC: p = 0.49; TA vs FE: p = 1; FC vs FE: p = 1). Comparison of IPSC amplitude in pre-adolescent, adolescent and adult TA groups: (F (2, 43) = 4.45, p = 0.017; pre-adolescent vs adolescent: p = 0.071; pre-adolescent vs adult: p = 1; adolescent vs adult: p < 0.031). Upper panels show example traces. Scale: 20 ms/200 pA.

Journal: Biological psychiatry

Article Title: Diminished fear extinction in adolescents is associated with an altered somatostatin interneuron-mediated inhibition in the infralimbic cortex

doi: 10.1016/j.biopsych.2019.04.035

Figure Lengend Snippet: Experience-dependent modulation of SSTIN-mediated inhibition of IL-mPFC layer 5 pyramidal neurons. A) Schematic presentation of light-evoked IPSC recording in the IL-mPFC layer 5 pyramidal neurons of SST-ChR2 mice. B) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of pre-adolescent tone alone (13 neurons/5 mice), fear conditioning (14 neurons/5 mice), and fear extinction groups (15 neurons/5 mice) (F (2, 39) = 1.14, p = 0.33; TA vs FC: p = 0.57; TA vs FE: p = 0.6; FC vs FE: p = 1). C) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adolescent tone alone (18 neurons/6 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (18 neurons/5 mice) (F (2, 48) = 7.8, p = 0.001; TA vs FC: p = 0.003; TA vs FE: p = 0.006; FC vs FE: p = 1). D) Mean IPSC amplitude in the IL-mPFC pyramidal neurons of adult tone alone (15 neurons/6 mice), fear conditioning (15 neurons/5 mice), and fear extinction groups (18 neurons/5 mice) (F (2, 45) = 1.05, p = 0.36; TA vs FC: p = 0.49; TA vs FE: p = 1; FC vs FE: p = 1). Comparison of IPSC amplitude in pre-adolescent, adolescent and adult TA groups: (F (2, 43) = 4.45, p = 0.017; pre-adolescent vs adolescent: p = 0.071; pre-adolescent vs adult: p = 1; adolescent vs adult: p < 0.031). Upper panels show example traces. Scale: 20 ms/200 pA.

Article Snippet: For conditioning, a mouse was placed in the conditioning chamber (context A) within a soundproof box (Coulbourn Instruments).

Techniques: Inhibition, Comparison